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Plant Based Pediococcus probiotic (PA5051®) shows effects on weight management

Updated: Oct 4, 2019

A new pilot study recently published in CDN (Current Developments In Nutrition) concluded that Pediococcus acidilactici NRRL B-50517 (PA5051®) is a safe probiotic for human consumption and may be useful in reducing body fat and pro-inflammatory markers. The study is entitled “Pediococcus Acidilactici NRRL B-50517 as a Safe Probiotic for Regulation of Weight-Related Pro-inflammatory Cytokines: A Double-blind Placebo-controlled Pilot Study (P21-026-19).”

Prepared by Dr. Jhy Jhu Lin, Imagilin Technology, LLC; Dr. Jeanne O'Connell, Restorasis Health at Sylvana Institute; and Dr. Steve Sinclair, Healing Power of Nature, the study was conducted over a three-month period. The goal was to determine the effectiveness of the probiotic PA5051® in resisting high temperatures (up to 85°C), stomach acids and the air. A clinical evaluation of the effectiveness of PA5051® as a safe probiotic for the regulation of weight-related health issues was also observed. 30 healthy participants were randomly assigned two capsules of placebo or PA5051

(4 billion CFU) to be taken daily for three months. In order to ensure proper daily dosage administration and to collect the results of a questionnaire relating to 6 categories of gut functions for safety evaluation, bi-weekly phone interviews were conducted. Both percent of body fat and serum preparation for cytokine analysis were performed at the beginning and the end of clinic study.

No statistical differences between control group and PA5051® treated group were observed from all 6 categories of gut functions- appetite, energy, bowel movement, stool quality, bloating and gas through the three months study. This demonstrates that PA5051® is the safe probiotics for human consumption. Interestingly, after taken three months with PA5051® probiotics, the PA5051® treated group showed a ~3 folds decreases in percent of body fat, 5 folds decrease in cytokine IL-6 and ~2.6 folds decrease in cytokine IL-23 comparing those of control group. This indicates that PA5051® may be applied for body weight management.


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